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We investigated the lipoprotein distribution and composition in cerebrospinal fluid (CSF) in a group of patients with Alzheimer's disease (AD) or affected by other types of dementia in comparison to non-demented controls. In analogy with the metabolism of lipids in the peripheral circulation, cerebrospinal fluid (CSF) lipids are transported by lipoproteins.We found slightly decreased apolipoprotein (apo)E and cholesterol concentrations in CSF of AD patients and moderately increased apo A-I concentrations, while in patients suffering from other types of dementia the apo A-I CSF concentration was increased. Although several reports describe the composition of CSF lipoproteins (4, 8–12), their detailed structure and functions are only poorly understood. Apo E plays an important role in the cholesterol metabolism, both in the peripheral circulation and in the brain, where it is synthesized by astrocytes and glial cells. It is clearly established that the inheritance of the apolipoprotein (apo) E4 allele is associated with increased risk of developing AD at a younger age (1, 3).
Characterization and functional studies of lipoproteins, lipid transfer proteins, and lecithin:cholesterol acyltransferase in CSF of normal individuals and patients with Alzheimer's disease.
In humans, such pre β particles have not yet been identified, and one of the aims of this study is to identify such precursor particles and the factors that may remodel them.
These small particles are likely candidates for participating in the process of “reverse cholesterol transport” as has been suggested for the interstitial fluid lipoproteins. (19) have demonstrated a unique profile of HDL generation and cholesterol efflux from rat astrocytes, whereby cholesterol-rich (apo E-HDL) and cholesterol-poor (apo A-I-HDL) are generated.
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