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In this study, we carried out a detailed analysis of lipids and lipoproteins in CSF collected from patients affected by AD, by other forms of dementia, or from non-demented controls in order to look for major differences in the lipid and lipoprotein composition among the different diagnostic groups.
Val is very familiar with Couples Resorts and has stayed at all resorts at least once and at Couples Negril three times.She has arranged several weddings at the Negril location and holds the Couples Resort certification.Val has recently completed Princess Cruises "Alaska Expert" program. Several observations suggest a close relationship between the lipoprotein metabolism in the brain and the development of Alzheimer's disease (AD) (1, 2). Characterization and functional studies of lipoproteins, lipid transfer proteins, and lecithin:cholesterol acyltransferase in CSF of normal individuals and patients with Alzheimer's disease.In humans, such pre β particles have not yet been identified, and one of the aims of this study is to identify such precursor particles and the factors that may remodel them.These small particles are likely candidates for participating in the process of “reverse cholesterol transport” as has been suggested for the interstitial fluid lipoproteins. (19) have demonstrated a unique profile of HDL generation and cholesterol efflux from rat astrocytes, whereby cholesterol-rich (apo E-HDL) and cholesterol-poor (apo A-I-HDL) are generated.In order to understand how the HDL particles in the brain compartment are synthesized and remodeled, we investigated in human CSF the presence of minor lipoprotein subclasses such as preβ particles by bi-dimensional non-denaturing gel electrophoresis.The physiological role of CSF lipoproteins as substrates for lipolytic enzymes such as lecithin:cholesterol acyltransferase (LCAT), and for lipid transfer proteins such as cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP) was investigated.Apo A-IV concentrations varied widely in human CSF, but were not associated with any clinical condition. CSF lipoproteins are needed for delivery of cholesterol during nerve growth, but it is not known whether they are also actively involved in taking up excess cholesterol from nerve cells.HDL density range, while apo A-IV was not associated with lipoproteins but appeared in a lipid-free form, co-localizing with LCAT immunoreactivity. This cholesterol could then be removed from the CSF via arachnoid granulations or by redistribution to other cells in the brain compartment (9).